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US mathematician John Nash, who inspired the Oscar-winning film A Beautiful Mind, has died in a car crash with his wife, police have said.
Nash, 86, and his 82-year-old wife Alicia were killed when their taxi crashed in New Jersey, they said.
The mathematician is renowned for his work in game theory, winning the Nobel Prize for Economics in 1994.
His breakthroughs in maths - and his struggles with schizophrenia - were the focus of the 2001 film.
Russell Crowe, who played him in the film, tweeted: "Stunned... My heart goes out to John & Alicia & family. An amazing partnership. Beautiful minds, beautiful hearts."
Alicia Nash helped care for her husband, and the two later became prominent mental health advocates.
The two were thrown from their vehicle, police said. Media reports said the couple may not have been wearing seatbelts when they crashed.
Their taxi driver, and a passenger in another car, were also injured.
Nash married Alicia Larde in 1957, when he was a rising star in the maths world.
But he developed severe schizophrenia soon after, and Alicia had him committed several times. The couple divorced in 1962.
They stayed close, and his condition had begun to improve by the 1980s. They remarried in 2001.
Earlier this week, Nash received the Abel Prize, another top honour in the field of mathematics.