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The US state of Georgia has executed its only female death row inmate, Kelly Gissendaner, depite a plea of celemecy from the Pope - reported the SkyNews.
The parole board denied her a stay of execution and she was pronounced dead at 12.21am local time (5.21 BST) after a lethal injection.
Gissendaner asked for a final prayer before she died, according to prison spokeswoman Lisa Rodriguez-Presley.
The board was not swayed by her appeal, nor by a letter they received from Pope Francis' US representative seeking mercy for Gissendaner.
Archbishop Carlo Maria Vigano's message on the Pontiff’s behalf asked for a commutation of her sentence "to one that would better express both justice and mercy".
The Pope, who toured the US last week, is an outspoken opponent of the death penalty.
Gissendaner, 47, was convicted over the 1997 murder of her husband, but her lawyers argued she was a model inmate filled with remorse over the killing.