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Iraqi security forces have fired tear gas and gunshots as hundreds of ani-government protesters stormed Baghdad's heavily fortified Green Zone.
Demonstrators rushed toward the prime minister's office and the parliament building in what was the second attack on the Green Zone this month.
There are reports that some protesters were badly wounded, with one said to have been shot in the head.
The violence prompted Iraqi Prime Minister Haider al Abadi to impose a curfew across the capital until further notice.
Earlier in the day, a thousands of people, mostly young men, gathered outside the Green Zone walls.
Security forces pushed through the crowd on foot, firing volleys of tear gas to try and push the demonstrators back from the gates.
The violence quickly escalated.
Some posted jubilant photographs from inside the prime minister's office on social media sites.
The violence came more than two weeks after the Green Zone compound was first breached by Shi'ite protesters.
Iraqi security forces at the time largely stood down, allowing protesters to scale walls and pull down concrete barriers.
Mr al Abadi later replaced the head of the compound security.
The initial breach was largely carried out by supporters of powerful Shia cleric Moqtada al Sadr, and followed repeated delays to proposed government reform legislation.
Since then, Iraq's government has been gridlocked and the parliament unable to convene.
Meanwhile, a string of deadly bombings has killed more than 200 over the past couple of weeks in and around Baghdad.
The attacks, many claimed by the Islamic State group, follow territorial losses it has suffered at the hands of Iraqi forces backed by US-led coalition aircraft.