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Two people have been killed and more than 150 others injured when a plane - Boeing 777 - landed at San Francisco International Airport, according to the city fire department, Sky News reports.
The Asiana Airlines flight, coming from Seoul, South Korea, was believed to be carrying 291 passengers and 16 crew members.
The San Francisco Fire Department, said 181 people have been taken to various hospitals - 49 of whom are in a serious condition.
South Korea's transportation ministry said the tail of the plane hit the runway before it crashed.
A fire started when the plane landed and passengers were forced to use emergency inflatable slides to escape the aircraft, witnesses added.
Parts of the plane's tail and the landing gear were strewn across the runway. Footage showed the top of the fuselage had been burned away and one engine appeared to have broken off.
Terrorism had been ruled out as a cause of the accident, the FBI confirmed.